And until you have got a doctor-diagnosed deficiency in any of those nutrients that you simply can’t fill with food alone, there’s no real need to complement at all. "At greatest, tremendous-excessive doses of nutrients are buying you costly urine, and at worst, they might contribute to the event of chronic diseases," she says. While research present supplementing with high doses does assist build muscle mass and improve strength over time, it’s not pre-workout in the strict sense, in that timing doesn’t really matter. Taking smaller doses more steadily throughout the day could even be an possibility, but you should discuss any adjustments in your treatment timing or dosage together with your physician earlier than experimenting on your own. As an illustration, a 2017 study in the Journal of Clinical Oncology found that long-term supplementation with excessive doses of vitamin B6 and B12 may considerably enhance the chance of lung most cancers in males